Apoptolidin
Product Specifications
CAS Number
194874-06-1
Target
Apoptosis, Others, ATPase
Related Pathways
Membrane transporter/Ion channel, Apoptosis, Others
Bioactivity
Apoptolidin is an apoptosis inducer originally isolated from Nocardiopsis bacteria. It inhibits the mitochondrial F1FO ATPase (Ki = 4-5 μM) . Apoptolidin selectively kills transformed glial cells without significantly affecting untransformed cells. It also has antibiotic and antifungal actions.
Smiles
[H][C@]1(C[C@H](OC)[C@@H](O)CC\C=C(/C)\C=C/[C@@H](O[C@@H]2O[C@@H](C)[C@H](OC)[C@@H](O)[C@@H]2O)[C@H](C)\C=C(/C)\C=C(\C)/C=C(C)/C(=O)O1)[C@@H](O)[C@]1(O)O[C@H](C[C@H](COC)O[C@H]2C[C@](C)(O)[C@@H](O[C@H]3C[C@@H](OC)[C@H](O)[C@@H](C)O3)[C@H](C)O2)[C@H](C)[C@H](O)[C@H]1C |c:10,13,31,37,t:34|
Molecular Formula
C58H96O21
Molecular Weight
1129.385
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Frequently Asked Questions
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