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Chiauranib

Product Specifications

CAS Number

1256349-48-0

Target

PDGFR, VEGFR, FLT, Aurora Kinase, c-Fms, c-Kit

Related Pathways

Tyrosine Kinase/Adaptors, Cell Cycle/Checkpoint, Chromatin/Epigenetic, Angiogenesis

Purity

0.9922

Bioactivity

Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRα and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF1R, with IC50 values ranging from 1-9 nM.

Smiles

COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccc3N)ccnc2c1

Molecular Formula

C27H21N3O3

Molecular Weight

435.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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