Chiauranib
Product Specifications
CAS Number
1256349-48-0
Target
PDGFR|||VEGFR|||FLT|||Aurora Kinase|||c-Fms|||c-Kit
Related Pathways
Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Angiogenesis
Purity
0.9922
Bioactivity
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFR? and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF1R, with IC50 values ranging from 1-9 nM.
Smiles
COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccc3N)ccnc2c1
Molecular Formula
C27H21N3O3
Molecular Weight
435.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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