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Chiauranib

Product Specifications

CAS Number

1256349-48-0

Target

PDGFR|||VEGFR|||FLT|||Aurora Kinase|||c-Fms|||c-Kit

Related Pathways

Tyrosine Kinase/Adaptors|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Angiogenesis

Purity

0.9922

Bioactivity

Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related kinases (VEGFR1, VEGFR2, VEGFR3, PDGFR? and c-Kit), mitosis-related kinase Aurora B, and chronic inflammation-related kinase CSF1R, with IC50 values ranging from 1-9 nM.

Smiles

COc1ccc2c(Oc3ccc4c(cccc4c3)C(=O)Nc3ccccc3N)ccnc2c1

Molecular Formula

C27H21N3O3

Molecular Weight

435.47

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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