PF-5274857 hydrochloride
Product Specifications
CAS Number
1613439-62-5
Target
Others, Smo
Related Pathways
Others, Stem Cells
Bioactivity
PF-5274857 hydrochloride is a potent, orally active, selective Smo antagonist (IC50=5.8 nM, Ki=4.6 nM) that is permeable through the blood-brain barrier. It has research potential in various tumors, including brain tumors and brain metastases driven by activated Hh pathways.
Smiles
Cl.Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O
Molecular Formula
C20H26Cl2N4O3S
Molecular Weight
473.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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