Gallocyanine
Product Specifications
CAS Number
1562-85-2
Target
Others, Wnt/beta-catenin
Related Pathways
Stem Cells, Cytoskeletal Signaling, Others
Bioactivity
Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 μM), thereby activating Wnt/β-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.
Smiles
[Cl-].CN(C)c1ccc2nc3c(cc(O)c(O)c3[o+]c2c1)C(O)=O
Molecular Formula
C15H13ClN2O5
Molecular Weight
336.73
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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