LLP-3
Product Specifications
CAS Number
1453835-43-2
Target
Survivin, Others
Related Pathways
Apoptosis, Others
Bioactivity
Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5) ) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 μM) . It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.
Smiles
C(#N)C1=C(C=C(NC1=O)C2=C(O)C=CC(Cl)=C2)C3=CC(OCC4=CC=CC=C4)=CC(OCC5=CC=CC=C5)=C3
Molecular Formula
C32H23ClN2O4
Molecular Weight
534.99
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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