(2R,4R) -APDC (hydrate)

(2R,4R) -APDC hydrate ((2R,4R) -4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R) -APDC hydrate affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R) -APDC hydrate can be used in the study of epilepsy and other neurological diseases[1].

Product Specifications

Product Name Alternative

(2R,4R) -4-Aminopyrrolidine-2,4-dicarboxylic acid (hydrate)

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2r-4r-apdc-hydrate.html

Purity

98.0

Solubility

H2O : 20 mg/mL (ultrasonic;warming)

Smiles

O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O.O

Molecular Formula

C6H12N2O5

Molecular Weight

192.17

References & Citations

[1]Feng Y B, et al. Effects of the group II mGlu receptor agonist 2R, 4R-APDC on dentate gyrus cell proliferation in the adult rat brain after diffuse brain injury[J]. Neurological research, 2011, 33 (4) : 381-388.