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(±) 13 (14) -EpDPA

Product Specifications

CAS Number

895127-64-7

Target

Cytochromes P450, Others

Related Pathways

Metabolism, Others

Bioactivity

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±) 13 (14) -EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 μM. (±) 13 (14) -EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±) 13 (14) -EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.

Smiles

CC\C=C/C\C=C/CC1OC1C\C=C/C\C=C/C\C=C/CCC(O)=O

Molecular Formula

C22H32O3

Molecular Weight

344.495

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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