19,20-Epoxycytochalasin D
Product Specifications
CAS Number
191349-10-7
Target
Parasite, Others, Endogenous Metabolite
Related Pathways
Others, Microbiology/Virology, Metabolism
Bioactivity
19,20-Epoxycytochalasin D is a fungal metabolite that has been found in the endophytic fungus Nemania sp. UM10M. It is active against the chloroquine-sensitive and -resistant strains of P. falciparum (MIC = 0.4 ng/ml for both) without inducing cytotoxicity in Vero cells. It is cytotoxic to BT-549, LLC-PK11, and P388 cells (IC50s = 7.84, 8.4, and 0.16 µM, respectively) but not SK-MEL, KB, or SKOV3 cells up to a concentration of 10 µM.
Smiles
[H][C@]12[C@H](Cc3ccccc3)NC(=O)[C@@]11[C@H](OC(C)=O)[C@@H]3O[C@H]3[C@@](C)(O)C(=O)[C@@H](C)C\C=C\[C@@]1([H])[C@H](O)C(=C)[C@H]2C
Molecular Formula
C30H37NO7
Molecular Weight
523.626
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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