DD 03-171
Product Specifications
CAS Number
2366132-45-6
Target
PROTACs, Others, BTK
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, Others, Angiogenesis
Bioactivity
Potent and selective BTK Degrader (IC50 = 5.1 nM) ; degrades BTK in a proteasome- and CRBN-dependent manner. Suppresses BTK signaling and proliferation in mantle cell lymphoma (MCL) cells by degrading BTK, IKFZ1, and IKFZ3 (3 validated targets in B-cell malignancies) . Also degrades Ibrutinib-resistant C481S-BTK mutant cancer cells. Exhibits no binding against a panel of 468 kinases at 1 μM. Reduces tumor burden and extends survival in lymphoma patient-derived xenograft models.
Smiles
Cc1c(NC(=O)c2ccc(cc2)C(C)(C)C)cccc1-c1cn(C)c(=O)c(Nc2ccc(cc2)C(=O)N2CCN(CCCCCCNC(=O)CNc3cccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c34)CC2)n1
Molecular Formula
C55H62N10O8
Molecular Weight
991.163
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Mouse Monoclonal Kynureninase Antibody (OTI1H1) [Alexa Fluor 350]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP2-71400AF350 0.1 mL
Mouse Monoclonal Kynureninase Antibody (OTI1H1) [Alexa Fluor 350]
Sign In for Pricing
View Details 
ARP43757_P050-Biotin 100 µL
SLC2A9 Antibody - middle region : Biotin (ARP43757_P050-Biotin)
Sign In for Pricing
View Details 
GTR15101807 1 Vial
Lentiviral human PEX6 shRNA (UAS) - Lentiviral human PEX6 shRNA (UAS, RFP) (25)
Sign In for Pricing
View Details 