DBRD9-A

Product Specifications

CAS Number

2170679-42-0

Target

Others|||PROTACs|||Epigenetic Reader Domain

Related Pathways

PROTAC|||Chromatin/Epigenetic|||Others

Bioactivity

Potent BRD9 degrader. Selectively binds BRD9 and elicits near complete degradation of BRD9 at nanomolar concentrations. Inhibits growth of synovial sarcoma cells in vitro and tumor progression in a synovial sarcoma xenograft mouse model.

Smiles

O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC=CC2NCCCCCCCCNC(CN(CC4=C(OC)C=C(C=C4OC)C=5C=6C(C(=O)N(C)C5)=CN=CC6)C)=O

Molecular Formula

C42H49N7O8

Molecular Weight

779.88

Shipping Conditions

Cool pack

Storage Temperature

-20°C

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