(E) -5- (2-Bromovinyl) uracil
Product Specifications
CAS Number
69304-49-0
Target
Others, DNA/RNA Synthesis
Related Pathways
Cell Cycle/Checkpoint, DNA Damage/DNA Repair, Others
Bioactivity
(E) -5- (2-Bromovinyl) uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E) -5- (2-bromovinyl) -2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 μmol/kg, thereby increasing survival time.
Smiles
C(=C/Br)\C=1C(=O)NC(=O)NC1
Molecular Formula
C6H5BrN2O2
Molecular Weight
217.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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