(E) -5- (2-Bromovinyl) uracil

(E) -5- (2-Bromovinyl) uracil (BVU) is a pyrimidine base and an inactive metabolite of the antiviral agents sorivudine and (E) -5- (2-bromovinyl) -2'-deoxyuridine (BVDU), which can be regenerated to BVDU in vivo. BVU irreversibly inactivates dihydropyrimidine dehydrogenase (DPD) in an NADPH-dependent manner, enhancing the efficacy of the chemotherapeutic agent and DPD substrate 5-fluorouracil in a P388 murine leukemia model when administered at a dose of 200 ?mol/kg, thereby increasing survival time.