AC-4-130
Product Specifications
CAS Number
1834571-82-2
Target
STAT, Apoptosis, Others
Related Pathways
JAK/STAT signaling, Others, Apoptosis, Stem Cells
Bioactivity
AC-4-130, a powerful inhibitor of the SH2 domain of STAT5, effectively hinders STAT5 activation, dimerization, nuclear translocation, and transcription of genes reliant on STAT5. This compound directly binds to STAT5, ultimately leading to cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 exhibits notable anti-cancer properties and effectively suppresses abnormal STAT5 activity in acute myeloid leukemia (AML), making it a promising therapeutic option [1].
Smiles
CC(C)(C)c1cc(CN(C(=O)CN(Cc2ccc(Cl)cc2)S(=O)(=O)c2c(F)c(F)c(F)c(F)c2F)c2ccc(cc2)C(O)=O)cc(c1)C(C)(C)C
Molecular Formula
C37H36ClF5N2O5S
Molecular Weight
751.2
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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