AZD1283
Product Specifications
CAS Number
919351-41-0
Target
P2Y Receptor
Related Pathways
GPCR/G Protein, Neuroscience
Purity
0.9963
Bioactivity
AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM) . AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithrombotic ED50 values of 3.0 and 10 μg/kg/min, respectively. The doses induced the increase in bleeding time at 33 and 100 μg/kg/min for 3- and 13-fold, respectively. Thus, the therapeutic index (TI) was ≥10 for both compounds.
Smiles
CCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1
Molecular Formula
C23H26N4O5S
Molecular Weight
470.54
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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