LDN-193189 2HCl
Product Specifications
CAS Number
1435934-00-1
Target
TGF-beta/Smad, ALK
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors, Stem Cells
Purity
0.99876
Bioactivity
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively. LDN-193189 2HCl inhibited the transcriptional activity of BMP type I receptors ALK2 and ALK3 in C2C12 cells, with IC50s of 5 nM and 30 nM, respectively, and was 200-fold more selective for BMP than for TGF-β.
Smiles
C1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl
Molecular Formula
C25H24Cl2N6
Molecular Weight
479.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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