H-1152 dihydrochloride
Product Specifications
CAS Number
871543-07-6
Target
ROCK
Related Pathways
Cytoskeletal Signaling, Cell Cycle/Checkpoint, Stem Cells
Purity
0.9985
Bioactivity
H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.
Smiles
Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12
Molecular Formula
C16H23Cl2N3O2S
Molecular Weight
392.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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