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H-1152 dihydrochloride

Product Specifications

CAS Number

871543-07-6

Target

ROCK

Related Pathways

Cytoskeletal Signaling, Cell Cycle/Checkpoint, Stem Cells

Purity

0.9985

Bioactivity

H-1152 dihydrochloride (H-1152 2HCl) is a specific inhibitor of Rho-associated protein kinase (ROCK) with an IC50 of 12 nM and a Ki of 1.6 nM. H-1152 dihydrochloride inhibits PKA, PKC, PKG, Aurora A and CaMKII with IC50 values of 3.03 μM, 5.68 μM, 0.360 μM, 0.745 μM and 0.180 μM, respectively.

Smiles

Cl.Cl.C[C@H]1CNCCCN1S(=O)(=O)c1cccc2cncc(C)c12

Molecular Formula

C16H23Cl2N3O2S

Molecular Weight

392.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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