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Senicapoc

Product Specifications

CAS Number

289656-45-7

Target

Potassium Channel

Related Pathways

Membrane transporter/Ion channel

Purity

0.995

Bioactivity

Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.

Smiles

NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1

Molecular Formula

C20H15F2NO

Molecular Weight

323.34

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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