Senicapoc
Product Specifications
CAS Number
289656-45-7
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.995
Bioactivity
Senicapoc (ICA-17043) is a potent inhibitor of the Gardos channel that ameliorates RBC dehydration in the SAD mouse. It blocks Ca2+-induced rubidium flux from human RBCs with an IC50 value of 11 ± 2 nM (CLT IC50 = 100 ± 12 nM) and inhibits RBC dehydration with an IC50 of 30 ± 20 nM. Senicapoc is used in the treatment of Sickle Cell Disease and Sickle Cell Anemia.
Smiles
NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Molecular Formula
C20H15F2NO
Molecular Weight
323.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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