Setipiprant
Product Specifications
CAS Number
866460-33-5
Target
Prostaglandin Receptor, GPCR
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Endocrinology/Hormones
Purity
0.9971
Bioactivity
Setipiprant (ACT-129968) is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM) . CRTH2, a G protein-coupled receptor for prostaglandin (PGD2), mediates key inflammatory responses related to allergy and asthma. PGD2, produced by mast cells, binds to CRTH2 on blood-borne cells, inducing chemotaxis of Th2 cells, basophils, and eosinophils, and stimulating cytokine release.
Smiles
C(C(O)=O)N1C2=C(C=3C1=CC=C(F)C3)CN(C(=O)C=4C5=C(C=CC4)C=CC=C5)CC2
Molecular Formula
C24H19FN2O3
Molecular Weight
402.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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