RO8994
Product Specifications
CAS Number
1309684-94-3
Target
Apoptosis, E1/E2/E3 Enzyme, Mdm2, MDM-2/p53, p53
Related Pathways
Apoptosis, Ubiquitination
Purity
0.9944
Bioactivity
RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays) .
Smiles
COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O
Molecular Formula
C31H31Cl2FN4O4
Molecular Weight
613.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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