RO8994

Product Specifications

CAS Number

1309684-94-3

Target

Apoptosis|||E1/E2/E3 Enzyme|||Mdm2|||MDM-2/p53|||p53

Related Pathways

Apoptosis|||Ubiquitination

Purity

0.9944

Bioactivity

RO8994 is a highly effective and specific inhibitor of spiroindolinone small-molecule MDM2, with IC50 of 20 nM (MTT proliferation assays) and 5 nM (HTRF binding assays) .

Smiles

COc1cc(ccc1NC(=O)[C@@H]1N[C@@H](CC(C)(C)C)[C@]2([C@H]1c1cccc(Cl)c1F)C(=O)Nc1cc(Cl)ccc21)C(N)=O

Molecular Formula

C31H31Cl2FN4O4

Molecular Weight

613.51

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

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