GSK180736A
Product Specifications
CAS Number
817194-38-0
Target
ROCK|||GRK|||PKA
Related Pathways
GPCR/G Protein|||Stem Cells|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors
Purity
0.9898
Bioactivity
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 ?M) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 ?M), but highly effective against ROCK1 (IC50: 100 nM) .
Smiles
CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1
Molecular Formula
C19H16FN5O2
Molecular Weight
365.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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