GSK180736A

Product Specifications

CAS Number

817194-38-0

Target

ROCK|||GRK|||PKA

Related Pathways

GPCR/G Protein|||Stem Cells|||Cell Cycle/Checkpoint|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

Purity

0.9898

Bioactivity

GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 ?M) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 ?M), but highly effective against ROCK1 (IC50: 100 nM) .

Smiles

CC1=C(C(NC(=O)N1)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1

Molecular Formula

C19H16FN5O2

Molecular Weight

365.36

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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