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Nazartinib

Product Specifications

CAS Number

1508250-71-2

Target

EGFR

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

Purity

0.9962

Bioactivity

Nazartinib (EGF816) (EGF816, NVS-816) is a covalent, irreversible, mutant-selective EGFR inhibitor that has nanomolar inhibitory potency against activating mt (L858R, ex19del) and T790M mt, with up to 60-fold selectivity over wild type (wt) EGFR in vitro.

Smiles

CN(C)C\C=C\C(=O)N1CCCC[C@H](C1)n1c(NC(=O)c2ccnc(C)c2)nc2cccc(Cl)c12

Molecular Formula

C26H31ClN6O2

Molecular Weight

495.02

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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