MC-Val-Cit-PABC-PNP
Product Specifications
CAS Number
159857-81-5
Target
AChR, ADC Linker
Related Pathways
Neuroscience, Antibody-drug Conjugate/ADC Related
Purity
0.9913
Bioactivity
MC-Val-Cit-PABC-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker. For example, FDA approved drug, brentuximab vedotin, adopts this linker. Protein- and peptide-drug conjugates hold a promising stance in the delivery of therapeutic agents by providing distinct advantage of improving therapeutic potential of drugs. Use of specialized linkers makes them unique in their in vivo therapeutic application by providing target tissue-specific release of drug.
Smiles
[C@H](C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1)=O)(NC([C@@H](NC(CCCCCN3C(=O)C=CC3=O)=O)C(C)C)=O)CCCNC(N)=O
Molecular Formula
C35H43N7O11
Molecular Weight
737.76
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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