Chelidonic acid

Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].

Product Specifications

CAS Number

[99-32-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Caspase; NF-κB

Type

Natural Products

Related Pathways

Apoptosis; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Chelidonic_acid.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.5 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(C=C(C(O)=O)O1)=O)O

Molecular Formula

C7H4O6

Molecular Weight

184.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Shin HJ, et al. Inhibitory effects of chelidonic acid on IL-6 production by blocking NF-κB and caspase-1 in HMC-1 cells. Immunopharmacol Immunotoxicol. 2011 Dec;33 (4) :614-9.|[2]Porter TG, et al. Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase. Biochem Pharmacol. 1985 Dec 1;34 (23) :4145-50.|[3]Oh HA, et al. Beneficial effects of chelidonic acid on a model of allergic rhinitis. Send to Int Immunopharmacol. 2011 Jan;11 (1) :39-45.