LX7101
LX7101 is a potent LIM-kinase, ROCK and PKA inhibitor with IC50s of 24 nM, 1.6 nM, 10 nM and 50 values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research[1][2].
Product Specifications
CAS Number
1192189-69-7
UNSPSC
12352005
Target
LIM Kinase (LIMK) ; PKA; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/LX7101.html
Purity
99.54
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
NCC1(C(NC2=CC(OC(N(C)C)=O)=CC=C2)=O)CCN(C3=C4C(NC=C4C)=NC=N3)CC1
Molecular Formula
C23H29N7O3
Molecular Weight
451.52
References & Citations
[1]Boland S, et al. Design, synthesis and biological characterization of selective LIMK inhibitors. Bioorganic & Medicinal Chemistry Letters (2015), 25 (18), 4005-4010.|[2]Harrison BA, et al. Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma. ACS Medicinal Chemistry Letters (2015), 6 (1), 84-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
ROCK2
Available Sizes
Frequently Asked Questions
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