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Org 6906

Org 6906 is a monoamine reuptake inhibitor that promotes monoaminergic neurotransmission by inhibiting the reuptake of noradrenaline, dopamine, and serotonin. Org 6906 is also an α2 Adrenergic Receptor antagonist, with a pKi value of 6.3 (using the selective α2 adrenergic receptor ligand [3H]rauwolscine as a ligand) . Org 6906 exhibits antidepressant activity and can be used in research related to neurological disorders[1].

Product Specifications

CAS Number

[67384-25-2]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/org-6906.html

Smiles

N[C@H]1[C@@]2([H])C[C@](C=C1)([H])C3=CC=CC=C3C2.Cl

Molecular Formula

C13H16ClN

Molecular Weight

221.73

References & Citations

[1]de Boer T, et al. The pharmacological profile of Org 6906, a potential non-sedative antidepressant that combines monoamine uptake inhibition with alpha 2-adrenolytic activity. Neuropharmacology. 1988 Mar;27 (3) :251-60.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

α adrenergic receptor

Curated Selection

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