TAS-119
Product Specifications
CAS Number
1453099-83-6
Target
Aurora Kinase
Related Pathways
Cell Cycle/Checkpoint, Chromatin/Epigenetic
Purity
0.9965
Bioactivity
TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95 nM.TAS-119 has a higher affinity for Aurora A than for Aurora B.TAS-119 exhibits potent antitumor activity and potential antimitotic activity. TAS-119 has potent anti-tumor activity and potential anti-mitotic activity.
Smiles
Cc1cc(Nc2nc(CC3(CCN(CC3)C(=O)c3cccc(Cl)c3Cl)C(O)=O)ccc2F)n[nH]1
Molecular Formula
C23H22Cl2FN5O3
Molecular Weight
506.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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