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Ro 67-7476

Product Specifications

CAS Number

298690-60-5

Target

GluR

Related Pathways

Neuroscience

Purity

0.9969

Bioactivity

Ro 67-7476 is a positive allosteric modulator of mGluR1, which can enhance the calcium release induced by glutamate in HEK293 cells expressing rat mGluR1a. The EC50 is 60.1 nM. It is a P-ERK1/2 agonist, and can activate ERK1/2 phosphorylation without the addition of exogenous glutamate (EC50 = 163.3 nM) .

Smiles

Cc1ccc(cc1)S(=O)(=O)N1CCC[C@H]1c1ccc(F)cc1

Molecular Formula

C17H18FNO2S

Molecular Weight

319.39

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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