DHPG

DHPG is the agonist for mGluR 1/5 (EC50 for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) [1].

Product Specifications

CAS Number

[146255-66-5]

Product Name Alternative

(RS) -3,5-DHPG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dhpg.html

Purity

99.60

Solubility

DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 2 with HCl) |H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(N)C1=CC(O)=CC(O)=C1

Molecular Formula

C8H9NO4

Molecular Weight

183.16

Precautions

H302, H315, H319, H335

References & Citations

[1]Winder DG, et al. Metabotropic glutamate receptor (mGluR) -mediated potentiation of cyclic AMP responses does not require phosphoinositide hydrolysis: mediation by a group II-like mGluR. J Neurochem. 1995 Feb;64 (2) :592-9.|[2]Pellegrini-Giampietro DE, et al. Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus. Br J Pharmacol. 1996 Jun;118 (4) :1035-43.|[3]Scotland PE, et al., Enhanced 3,5-dihydroxyphenylglycine-induced sustained nociceptive behaviors in rats with neuropathy or chronic inflammation. Behav Brain Res. 2007 Dec 3;184 (2) :150-6.