Merestinib
Product Specifications
CAS Number
1206799-15-6
Target
ROS, ROS Kinase, FLT, c-Met/HGFR, Discoidin Domain Receptor (DDR)
Related Pathways
Angiogenesis, Immunology/Inflammation, Tyrosine Kinase/Adaptors
Purity
0.9971
Bioactivity
Merestinib (LY2801653) is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. Merestinib electively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
Smiles
O(C1=C(C=C2C(=C1)C=NN2C)C=3C=NNC3)C4=C(F)C=C(NC(=O)C=5C(=O)N(C(C)=CC5)C6=CC=C(F)C=C6)C=C4
Molecular Formula
C30H22F2N6O3
Molecular Weight
552.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
146136 100 µg
PEN2, NT (PSENEN, Presenilin Enhancer Protein 2, Gamma-secretase Subunit PEN-2, MDS033, MSTP064)
Sign In for Pricing
View Details 
MBS7017539-01 0.02 mg
Recombinant Iron import ATP-binding/permease protein IrtB (irtB)
Sign In for Pricing
View Details MBS7017539-02 0.1 mg
Recombinant Iron import ATP-binding/permease protein IrtB (irtB)
Sign In for Pricing
View Details 
MBS7017539-03 5x 0.1 mg
Recombinant Iron import ATP-binding/permease protein IrtB (irtB)
Sign In for Pricing
View Details AM4077 2 OD, 4 OD, 50 OD
MIRacle™ mmu-miR-6997-5p miRNA Agomir/Antagomir
Sign In for Pricing
View Details