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PQA-18

PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM) . PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice[1].

Product Specifications

CAS Number

1604678-82-1

UNSPSC

12352005

Target

Interleukin Related; PAK; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pqa-18.html

Purity

99.62

Smiles

O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC/C=C(C)/C)=C1)OC/C=C(C)\C

Molecular Formula

C25H31NO4

Molecular Weight

409.52

References & Citations

[1]Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-2; IL-4; IL-6; PAK2

Available Sizes

Frequently Asked Questions

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