PQA-18
PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM) . PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice[1].
Product Specifications
CAS Number
1604678-82-1
UNSPSC
12352005
Target
Interleukin Related; PAK; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pqa-18.html
Purity
99.62
Smiles
O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC/C=C(C)/C)=C1)OC/C=C(C)\C
Molecular Formula
C25H31NO4
Molecular Weight
409.52
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-2; IL-4; IL-6; PAK2
Available Sizes
Frequently Asked Questions
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