Amentoflavone
Product Specifications
CAS Number
1617-53-4
Target
COX, Antifungal, GABA Receptor, Apoptosis, Cytochromes P450, Opioid Receptor, Reactive Oxygen Species, Phospholipase, ROS, Antibacterial, RSV
Related Pathways
Microbiology/Virology, Immunology/Inflammation, Neuroscience, GPCR/G Protein, Metabolism, Endocrinology/Hormones, Apoptosis, NF-κB, Membrane transporter/Ion channel
Purity
0.9922
Bioactivity
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the Delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having the dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted suppression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
Smiles
Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)c(-c3cc(ccc3O)-c3cc(=O)c4c(O)cc(O)cc4o3)c2o1
Molecular Formula
C30H18O10
Molecular Weight
538.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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