Glabridin

Metabolism, NF-κB, Proteases/Proteasome, Membrane transporter/Ion channel, Neuroscience, DNA Damage/DNA Repair, Microbiology/Virology, Immunology/Inflammation

Glabridin (KB-289522) may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders (such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.