Timosaponin AIII
Product Specifications
CAS Number
41059-79-4
Target
Cholinesterase (ChE) |||mTOR
Related Pathways
PI3K/Akt/mTOR signaling|||Neuroscience
Purity
0.9961
Bioactivity
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 ?M) . The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 ?M, BT474 cells; 6 ?M, MDAMB231) . The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
Smiles
C[C@@]12[C@@]3([C@](C[C@]1([C@]4([C@](CC2)([C@]5(C)[C@](CC4)(C[C@@H](O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@@H](O)[C@@H](CO)O6)CC5)[H])[H])[H])[H])(O[C@@]8([C@H]3C)CC[C@H](C)CO8)[H])[H]
Molecular Formula
C39H64O13
Molecular Weight
740.92
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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