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PF-04856264

Product Specifications

CAS Number

1235397-05-3

Target

Sodium Channel

Related Pathways

Membrane transporter/Ion channel

Purity

0.9743

Bioactivity

PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.

Smiles

N#CC1=CC(=CC=C1OC=2C=CC=CC2C3=CC=NN3C)S(=O)(=O)NC4=NC=CS4

Molecular Formula

C20H15N5O3S2

Molecular Weight

437.5

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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