PF-04856264
Product Specifications
CAS Number
1235397-05-3
Target
Sodium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9743
Bioactivity
PF-04856264 is a Nav1.7 blocker.Nav1.7 is a chondrocyte modulator and a therapeutic target in osteoarthritis.Inhibition of Nav1.7 modulates intracellular Ca 2+ signaling and chondrocyte secretome, raises the threshold of mechanical pain and inhibits ERK expression, which has analgesic and anti-inflammatory effects.
Smiles
N#CC1=CC(=CC=C1OC=2C=CC=CC2C3=CC=NN3C)S(=O)(=O)NC4=NC=CS4
Molecular Formula
C20H15N5O3S2
Molecular Weight
437.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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