NSC 109555
Product Specifications
CAS Number
15427-93-7
Target
Others, Autophagy, Chk
Related Pathways
Autophagy, Others, Cell Cycle/Checkpoint
Bioactivity
NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM) . Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.
Smiles
CS(O)(=O)=O.CS(O)(=O)=O.C\C(=N/N=C(N)N)c1ccc(NC(=O)Nc2ccc(cc2)C(\C)=N\N=C(N)N)cc1
Molecular Formula
C21H32N10O7S2
Molecular Weight
600.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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