Jervine
Product Specifications
CAS Number
469-59-0
Target
Hedgehog/Smoothened, Smo
Related Pathways
Stem Cells, GPCR/G Protein
Purity
0.9986
Bioactivity
The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
Smiles
[H][C@@]12NC[C@@H](C)C[C@H]1O[C@]1(CC[C@]3([H])C(C(=O)[C@@]4([H])[C@@]3([H])CC=C3C[C@@H](O)CC[C@]43C)=C1C)[C@@H]2C
Molecular Formula
C27H39NO3
Molecular Weight
425.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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