7ACC1

7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1) /MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers[1][2][3].

Product Specifications

CAS Number

[50995-74-9]

Product Name Alternative

DEAC; Coumarin D 1421; D 1421

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Monocarboxylate Transporter

Type

Dye Reagents

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/7ACC1.html

Purity

99.97

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)O

Molecular Formula

C14H15NO4

Molecular Weight

261.28

Precautions

H302, H315, H319, H335

References & Citations

[1]Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13 (6) :1410-8.|[2]Guo C, et al. Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. Cancer Cell Int. 2019 Jun 28;19:170. |[3]Mohamed F A, et al. Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction[J]. Blood, 2023, 142: 459.