ZK 756326
Product Specifications
CAS Number
874911-96-3
Target
CCR
Related Pathways
GPCR/G Protein, Immunology/Inflammation, Microbiology/Virology
Purity
0.9943
Bioactivity
ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse) . Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors) . Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
Smiles
Cl.Cl.OCCOCCN1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Molecular Formula
C21H28N2O3
Molecular Weight
356.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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