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Naldemedine

Product Specifications

CAS Number

916072-89-4

Target

Others, Opioid Receptor

Related Pathways

GPCR/G Protein, Endocrinology/Hormones, Others, Neuroscience

Bioactivity

Naldemedine (S 297995) is a peripheral selective μ-opioid receptor antagonist being developed by Shionogi for the treatment of opioid-induced adverse reactions, including constipation, nausea, and vomiting. They are usually well tolerated, mainly with mild to moderate gastrointestinal side effects.

Smiles

O[C@]12[C@@]34C=5C(O[C@]3(C(O)=C(C(NC(C)(C)C6=NC(=NO6)C7=CC=CC=C7)=O)C1)[H])=C(O)C=CC5C[C@]2(N(CC8CC8)CC4)[H]

Molecular Formula

C32H34N4O6

Molecular Weight

570.64

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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