Niraparib hydrochloride
Product Specifications
CAS Number
1038915-64-8
Target
PARP, Apoptosis
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic
Purity
0.9985
Bioactivity
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.
Smiles
C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl
Molecular Formula
C19H21ClN4O
Molecular Weight
356.85
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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