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Niraparib hydrochloride

Product Specifications

CAS Number

1038915-64-8

Target

PARP, Apoptosis

Related Pathways

DNA Damage/DNA Repair, Apoptosis, Chromatin/Epigenetic

Purity

0.9985

Bioactivity

Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.

Smiles

C(N)(=O)C=1C=2C(=CN(N2)C3=CC=C(C=C3)[C@@H]4CCCNC4)C=CC1.Cl

Molecular Formula

C19H21ClN4O

Molecular Weight

356.85

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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