MSC 2032964A
Product Specifications
CAS Number
1124381-43-6
Target
ASK, p38 MAPK, MAPK
Related Pathways
MAPK, Apoptosis
Purity
>99.99%
Bioactivity
MSC 2032964A is a potent selective ASK1 inhibitor (IC50 = 93 nM) that is oral bioavailable and brain permeable. It inhibited neuroinflammation in mouse EAE models and blocked LPS-induced phosphorylation of ASK1 and p38 in cultured mouse astrocytes.
Smiles
FC(F)(F)c1cc(NC2CC2)n2nc(NC(=O)c3cccnc3)nc2c1
Molecular Formula
C16H13F3N6O
Molecular Weight
362.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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